Kylian Mbappe was forced out of Paris Saint-Germain's victory over Toulouse on Sunday as the forward became the third player to suffer an injury on the day for the French champions.
The striker grabbed the back of his leg and had to leave the match in the 66th minute, suffering an apparent hamstring injury that ended his day prematurely.
Mbappe walked down the tunnel with a team physio, as 17-year-old defender Arthur Zagre took his place in the PSG lineup.
The injury was the third of the day suffered by a PSG player, as Edinson Cavani and Abdou Diallo were also forced out of the match.
Cavani's injury occurred just 14 minutes into the match as the Uruguayan forward appeared to tweak his groin, prompting an immediate substitution.
He was replaced by Eric Maxim Choupo-Moting, who provided a pair of goals for PSG in the 4-0 win.
Diallo, meanwhile, lasted until the 40th minute before exiting following an aerial duel. Brazilian defender Thiago Silva took his place.
Mbappe had played all 90 minute in each of PSG's first two matches of the Ligue 1 campaign, having scored in a 3-0 season-opening win against Nimes.
However, he was held scoreless in the second match against Rennes as PSG were stunned 2-1.
The Frenchman scored 33 league goals in 29 appearances last campaign, helping PSG win the league once again.
He also scored four goals in eight Champions League appearances, although PSG were stunned by Manchester United in the round of 16 in last year's tournament.
PSG have been without Neymar to start the season, and the Brazilian star did not dress once again in the victory over Toulouse.
Choupo-Moting was joined on the scoresheet by defender Marquinihos, who scored the fourth and final goal, and PSG also were on the receiving end of an own goal from Matthieu Goncalves.
Next up for PSG is a visit to Metz on Friday before the start of the first international break of the campaign.
After that, the French champions will return home to the Parc de Princes to host Strasbourg on September 14.
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